As of the census of 2000, there were 28,683 people, 12,543 households, and 7,663 families residing in the town. The population density was 1,305.2 people per square mile (503.8/km²). There were 13,342 housing units at an average density of 607.1/sq mi (234.4/km²). The racial makeup of the town was 94.05% white, 1.35% African American, 0.10% Native American, 2.72% Asian, 0.06% Pacific Islander, 0.53% from other races, and 1.20% from two or more races. Hispanic or Latino of any race were 2.57% of the population.
There were 12,543 households out of which 25.7% had children under the age of 18 living with them, 47.9% were married couples living together, 9.8% had a female householder with no husband present, and 38.9% were non-families. 32.4% of all households were made up of individuals and 11.6% had someone living alone who was 65 years of age or older. The average household size was 2.26 and the average family size was 2.90.
In the town the population was spread out with 20.7% under the age of 18, 5.4% from 18 to 24, 30.5% from 25 to 44, 26.6% from 45 to 64, and 16.9% who were 65 years of age or older. The median age was 41 years. For every 100 females there were 88.9 males. For every 100 females age 18 and over, there were 85.2 males.
The median income for a household in the town was $58,009, and the median income for a family was $69,510. Males had a median income of $46,927 versus $35,947 for females. The per capita income for the town was $32,301. About 3.3% of families and 4.1% of the population were below the poverty line, including 3.9% of those under the age of 18 and 4.0% of those 65 and older.
The main artery through the town is Interstate 95, running along the eastern coast of the United States. Between Branford and New Haven, the highway passes over the Pearl Harbor Memorial Bridge. The town has a station on the Shore Line East commuter rail line from New London to New Haven. The Branford Steam Railroad carries quarried traprock from North Branford to barges at Juniper Point near Stony Creek. Tweed New Haven Regional Airport is located three miles (5 km) west of Branford.