Berrien County was created 25 February 1856 out of portions of Coffee, Irwin and Lowndes counties by an act of the Georgia General Assembly. It is named after Georgia senator John M. Berrien.
As of the census of 2000, there were 16,235 people, 6,261 households, and 4,539 families residing in the county. The population density was 36 people per square mile (14/km²). There were 7,100 housing units at an average density of 16 per square mile (6/km²). The racial makeup of the county was 85.48% White, 11.43% Black or African American, 0.26% Native American, 0.30% Asian, 0.08% Pacific Islander, 1.53% from other races, and 0.92% from two or more races. 2.37% of the population were Hispanic or Latino of any race.
There were 6,261 households out of which 34.90% had children under the age of 18 living with them, 56.20% were married couples living together, 11.70% had a female householder with no husband present, and 27.50% were non-families. 23.60% of all households were made up of individuals and 10.00% had someone living alone who was 65 years of age or older. The average household size was 2.57 and the average family size was 3.03.
In the county the population was spread out with 27.20% under the age of 18, 8.60% from 18 to 24, 28.70% from 25 to 44, 22.90% from 45 to 64, and 12.50% who were 65 years of age or older. The median age was 35 years. For every 100 females there were 96.50 males. For every 100 females age 18 and over, there were 92.80 males.
The median income for a household in the county was $30,044, and the median income for a family was $34,643. Males had a median income of $25,559 versus $19,790 for females. The per capita income for the county was $16,375. About 14.60% of families and 17.70% of the population were below the poverty line, including 25.40% of those under age 18 and 13.00% of those age 65 or over.