As of the U.S.census estimate of 2007, there were 55,398 people, 22,659 households, and 14,093 families residing in the city. The population density was 1,198.4/km² (3,102.9/mi²). There were 24,302 housing units at an average density of 538.6/km² (1,394.7/mi²). The racial makeup of the city was 90.63% White, 6.90% African American, 0.51% Asian, 0.12% Native American, 0.02% Pacific Islander, 0.55% from other races, and 1.28% from two or more races. Hispanic or Latino of any race were 1.03% of the population.
There were 22,659 households out of which 28.8% had children under the age of 18 living with them, 44.7% were married couples living together, 13.9% had a female householder with no husband present, and 37.8% were non-families. 33.3% of all households were made up of individuals and 14.0% had someone living alone who was 65 years of age or older. The average household size was 2.29 and the average family size was 2.91.
In the city the population was spread out with 24.1% under the age of 18, 9.8% from 18 to 24, 27.4% from 25 to 44, 22.4% from 45 to 64, and 16.3% who were 65 years of age or older. The median age was 37 years. For every 100 females there were 87.6 males. For every 100 females age 18 and over, there were 82.6 males.
The median income for a household in the city was $31,867, and the median income for a family was $41,333. Males had a median income of $33,429 versus $21,457 for females. The per capita income for the city was $17,968. About 12.2% of families and 15.9% of the population were below the poverty line, including 20.9% of those under age 18 and 12.4% of those age 65 or over.
According to the 2007 census, the Owensboro Metropolitan Area includes Daviess, Hancock, and McLean counties.
US 60 and US 431 serve downtown Owensboro. US 231 and US 60 BYPASS form a partial beltway around Owensboro. KY 81,KY 56,KY 331,KY 298,KY 54, and KY 144 also serve the city.
Owensboro-Daviess County Regional Airport serves along with Evansville Regional Airport as one of the region's commercial airports.
The Owensboro Wagon Company, established in 1884, was one of the largest and most influential wagon company in the nation. With nearly eight styles or sizes of wagons, the company set the standard of quality at the turn of the 20th century.