As of the census of 2000, there were 107,219 people, 44,247 households, and 26,105 families residing in the city. The population density was 3,241.4 people per square mile (1,251.6/km²). There were 45,892 housing units at an average density of 1,390.2/sq mi (536.8/km²). The racial makeup of the city was 91.75% White, 2.10% African American, 0.30% Native American, 2.32% Asian, 0.04% Pacific Islander, 1.76% from other races, and 1.73% from two or more races. Hispanic or Latino of any race were 4.62% of the population.
The largest ancestry groups within the city's population are: French (34.5%), Irish (18.1%), English (10.0%), German (6.3%), and Italian (6.2%).
There were 44,247 households out of which 29.4% had children under the age of 18 living with them, 42.6% were married couples living together, 11.7% had a female householder with no husband present, and 41.0% were non-families. 31.7% of all households were made up of individuals and 10.3% had someone living alone who was 65 years of age or older. The average household size was 2.36 and the average family size was 3.00.
In the city the population was spread out with 23.7% under the age of 18, 9.5% from 18 to 24, 33.4% from 25 to 44, 20.5% from 45 to 64, and 12.9% who were 65 years of age or older. The median age was 35 years. For every 100 females there were 95.9 males. For every 100 females age 18 and over, there were 93.3 males.
The median income for a household in the city was $40,774, and the median income for a family was $50,039. Males had a median income of $34,287 versus $26,584 for females. The per capita income for the city was $21,244. 10.6% of the population and 7.7% of families were below the poverty line. Out of the total people living in poverty, 14.6% are under the age of 18 and 11.7% are 65 or older.
The city is served by Manchester-Boston Regional Airport, the fourth largest airport in New England. It is the secondary airport serving Boston, Massachusetts, and is used by most of the nation's major airlines, with the largest market share held by Southwest Airlines. The airport has international service to Toronto, Ontario, via Air Canada, although customs are handled in Toronto.
Interstates 93 and 293 and the Everett Turnpike are multi-lane highways that connect the metropolitan area to Concord and the White Mountains to the north and Nashua and Boston to the south. NH 101 is a four-lane highway eastbound from Manchester to Hampton, connecting the city with the southeastern part of the state and the seacoast, as well as Maine and the Massachusetts North Shore via Interstate 95. West of Manchester, NH 101 is a two-lane highway serving as the main artery to Keene, the Monadnock region, and other points in southwestern New Hampshire.
Public transportation is provided by the Manchester Transit Authority, which runs several bus routes throughout the city and surrounding areas. Concord Trailways and Boston Express run commuter services to Boston and other parts of the state. Vermont Transit Lines (affiliated with Greyhound Lines) has lines to Montreal.
With the planned expansion of Interstate 93 to eight lanes from Salem to Manchester, space will be reserved in the median for potential future commuter rail service along this corridor.