Tuttle is a largely agricultural community with a focus on wheat, cotton, corn, alfalfa hay, Bermuda grass hay, and cattle. Nearby Braum's Dairy, the largest farm in the area, is located just outside the city's limits and has a market presence spanning several states. The city serves as a minor bedroom community of Oklahoma City.
The town was named in 1902 after a local cattleman and rancher, J. H. (Jim) Tuttle.
As of the census of 2000, there were 4,294 people, 1,585 households, and 1,272 families residing in the city. The population density was 147.3 people per square mile (56.9/km²). There were 1,648 housing units at an average density of 56.5/sq mi (21.8/km²). The racial makeup of the city was 91.34% White, 4.98% Native American, 0.16% Asian, 0.09% from other races, and 3.42% from two or more races. Hispanic or Latino of any race were 2.21% of the population. 0% of the population is African American.
There were 1,585 households out of which 38.5% had children under the age of 18 living with them, 67.9% were married couples living together, 9.1% had a female householder with no husband present, and 19.7% were non-families. 16.3% of all households were made up of individuals and 6.8% had someone living alone who was 65 years of age or older. The average household size was 2.69 and the average family size was 3.02.
In the city the population was spread out with 26.7% under the age of 18, 8.5% from 18 to 24, 27.7% from 25 to 44, 26.4% from 45 to 64, and 10.7% who were 65 years of age or older. The median age was 37 years. For every 100 females there were 97.5 males. For every 100 females age 18 and over, there were 92.4 males.
The median income for a household in the city was $40,396, and the median income for a family was $48,682. Males had a median income of $35,599 versus $25,850 for females. The per capita income for the city was $18,250. About 4.5% of families and 5.8% of the population were below the poverty line, including 6.0% of those under age 18 and 10.2% of those age 65 or over.