As of the census of 2000, there were 25,919 people, 10,636 households, and 7,019 families residing in the city. The population density was 1,431.0 people per square mile (552.6/km²). There were 11,871 housing units at an average density of 655.4/sq mi (253.1/km²). The racial makeup of the city was 84.18% White, 2.99% African American, 6.27% Native American, 0.70% Asian, 0.03% Pacific Islander, 2.08% from other races, and 3.75% from two or more races. Hispanic or Latino of any race were 4.43% of the population.
According to the Center for Applied Economic Research at the Oklahoma State University, Ponca City's per-capital personal income for 2006 was $35,071, steadily climbing from the 2000 census numbers listed below.
There were 10,636 households out of which 31.4% had children under the age of 18 living with them, 51.3% were married couples living together, 11.1% had a female householder with no husband present, and 34.0% were non-families. 30.0% of all households were made up of individuals and 13.7% had someone living alone who was 65 years of age or older. The average household size was 2.38 and the average family size was 2.95.
In the city the population was spread out with 26.2% under the age of 18, 8.5% from 18 to 24, 25.5% from 25 to 44, 22.1% from 45 to 64, and 17.7% who were 65 years of age or older. The median age was 38 years. For every 100 females there were 90.7 males. For every 100 females age 18 and over, there were 85.8 males.
The median income for a household in the city in 2000 was $31,406, and the median income for a family was $39,846. Males had a median income of $32,283 versus $20,098 for females. The per capita income for the city was $17,732. About 12.7% of families and 16.0% of the population were below the poverty line, including 23.6% of those under age 18 and 9.3% of those age 65 or over.